Clinical Article on Desensitization Protocol

Desensitization Protocol for Crowns Using G5

By Harald O. Heymann DDS, MEd


G5 is a time and research proven desensitizer that works to prevent post-op sensitivity when placed under virtually any type of dental restoration. Based historically on the formulation of a dentin primer, G5 contains 5% glutaraldehyde, 35% HEMA, and water: a simple but highly effective composition.


Achieving optimal isolation prior to any cementation procedure is essential.

  • Prior to crown cementation, remove the temporary crown and clean the preparation of residual cement and debris. Air dry.

  • Using a microbrush, apply G5 sparingly using a scrubbing action on all surfaces of the tooth preparation for 30 seconds. (FIG. 1) Avoid contact of G5 with soft tissue.

  • After application, rinse the residual G5 from the tooth with a gentle stream of water for 5 seconds. (FIG. 2)

  • If using GI, RMGI, Zinc Phosphate or other non-bonding cements, blot away excess moisture and proceed with cementation according to manufacturer’s instructions.

  • If using a conventional adhesive resin cement, air dry or leave moist according to manufacturer’s instructions.

Apply G5 sparingly to avoid soft tissue contact. Scrub on the preparation for 30 seconds.

When rinsing, use a gentle stream of water to avoid soft tissue contact.


  1. G5 is bactericidal owing to the glutaraldehyde. Like chlorhexidine and other cavity disinfectants, it kills the “bugs.”
  2. Unlike most cavity disinfectants and desensitizers, G5 forms a series of “coagulation plugs” in the dentinal tubules, thereby reducing dentin permeability and fluid flow, critical keys to desensitization (based on Brännström’s Hydrodynamic Theory of Dental Pain). G5 does so by coagulating the plasma proteins (serum albumin) in the dentinal tubules.
  3. G5 is a very effective cross-linking agent (flocculant) that toughens the collagen to which dental primers bond through hybrid layer formation.
  4. G5 also has been shown to effectively resist the adverse effects of MMPs, proteolytic enzymes that if activated can deteriorate the dentin/resin bond.

It should be pointed out that G5 does not adversely effect bond strengths of any resin bonding agent or of any cement. It is unique among desensitizers in this regard.

Dr. Harald Heymann


Dr. Heymann is active in the clinical research of esthetic restorative materials and is the author of over 200 scientific publications. He is a member of the Academy of Operative Dentistry, the International Association of Dental Research, and is Past-President and a Fellow of the American Academy of Esthetic Dentistry. He is also a Fellow in the International College of Dentists, the American College of Dentists, and the Academy of Dental Materials. He also has served for many years as a consultant to the ADA. Dr. Heymann also has been the Co-Senior Editor of The Art and Science of Operative Dentistry, historically, the #1 selling dental textbook in the world. Dr. Heymann is also the Editor-in-Chief of the Journal of Esthetic and Restorative Dentistry. Dr. Heymann has given over 1,600 lectures on various aspects of esthetic dentistry worldwide and has received the Gordon J. Christensen Award for excellence as a CE speaker.

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